World No. 1 Serena Williams was defeated by Italy’s Roberta Vinci in the semi-finals at the US Open.

The 21-time Grand Slam champion’s missed out on the chance to complete the calendar Grand Slam after the American was defeated by unseeded Italian Roberta Vinci on Friday 2–6, 6–4, 6–4.

Following the match – of course twitter reacted with sadness regarding Serena’s run for the major Grand Slam.. Here are some of the best reactions from celebrities..!

Wow, what a crazy crazy entertaining match. Such a bummer for Serena but a great match between 2 world class athletes.

— Alex Morgan (@alexmorgan13) September 11, 2015

Serena Williams is the greatest player I’ve ever seen. That doesn’t change. Sometimes, the best player doesn’t win.

— Mike Greenberg (@Espngreeny) September 11, 2015

So proud of you, @SerenaWilliams. What you did this year was amazing. -mo #USOpen2015

— The First Lady (@FLOTUS) September 11, 2015

Those people who bought women’s finals tickets …….

— andyroddick (@andyroddick) September 11, 2015

So, I am devastated and stunned. We love you @serenawilliams so much. Sending lots of love always. #usopen2015

— Laverne Cox (@Lavernecox) September 11, 2015

Well when Serena breaks it off with Drake I’m here for you boo. My season is already in the crapper so no one will blame you.

— Lolo Jones (@lolojones) September 11, 2015

Meek mill watching this serena game and laughing to no one in particular

— Desus Nice (@desusnice) September 11, 2015

4 grand slam W in a row plus SF and people disappointed. Geez..

— ivo karlovic (@ivokarlovic) September 11, 2015

Don’t worry bout it @serenawilliams shake it off get next one!

— Jodie Meeks (@Jmeeks20) September 11, 2015